Chloroquine
Dosage schedule
Antimalarial
Dose
Schedule
Long term travel
Chloroquine
2 x 250mg Avloclor® tablets once weekly.
Take one week before travel to, throughout stay in and for four weeks after leaving endemic area.
Can be taken continuously for three years. Beyond this, regular ophthalmic examinations are recommended every three to six months.
Children’s doses
Calculate the dose by weight in kilograms (kg) rather than by the age for infants and children. The following doses are based on guidelines from the Public Health England Advisory Committee on Malaria Prevention (ACMP) and may differ from doses in patient information leaflets (PILs)/SPCs (off-licence doses should not be sold, but must be prescribed). Contact the NPA Pharmacy team for further advice.
The dose steps for chloroquine syrup are not the same as for chloroquine tablets, because the tablets differ from the syrup in chloroquine base content
It is preferable to avoid crushing tablets; however, chloroquine, proguanil, mefloquine and atovaquone/proguanil tablets may be crushed and mixed with jam, honey, pasteurised yoghurt, or similar foods for ease of administration to young children
Weight
Chloroquine base (155mg)
once weekly
Under 6.0kg
1/4 tablet
6.0–9.9kg
1/2 tablet
10.0–15.9kg
3/4 tablet
16.0–24.9kg
1 tablet
25.0–44.9kg
1 and 1/2 tablets
45kg and over
2 tablets
Weight
Chloroquine syrup (50mcg/5ml base)once weekly
Under 4.5kg…
Doxycycline or Atovaquone/proguanil
Dosage schedule
Antimalarial
Dose
Schedule
Long-term travel
Doxycycline
1 x 100mg Doxycycline tablet/capsule daily.
Take one to two days before travel to, throughout stay in and for four weeks after leaving endemic area.
Can be taken for up to two years and possibly longer if considered necessary.
OR
Atovaquone/proguanil
1 x (250mg/100mg) Atovaquone/proguanil tablet daily.
Take one to two days before travel to, throughout stay in and for seven days after leaving endemic area.
Can be taken for up to one year and possibly longer if considered necessary.However, individual SPCs must be checked carefully as licensed treatment periods may vary.
Children’s doses
Calculate the dose by weight in kilograms (kg) rather than by the age for infants and children. The following doses are based on guidelines from Public Health England Advisory Committee on Malaria Prevention (ACMP) and may differ from doses in patient information leaflets (PILs)/SPCs (off-licence doses should not be sold, but must be prescribed). Contact the NPA Pharmacy Services team for further advice.
It is preferable to avoid crushing tablets; however, chloroquine, proguanil, mefloquine and atovaquone/proguanil tablets may be crushed and mixed with jam, honey, pasteurised yoghurt or similar for ease of administration to young children. Tablets may be cut using tablet cutters where necessary.…
Chloroquine or proguanil
Dosage schedule
Antimalarial
Dose
Schedule
Long term travel
Chloroquine
2 x 250mg Avloclor® tablets once weekly.
Take one week before travel to, throughout stay in and for four weeks after leaving endemic area.
Can be taken continuously for three years. Beyond this, regular ophthalmic examinations are recommended every three to six months.
OR
Proguanil
2 x 100mg Paludrine® tablets daily
Take one week (or at least two days if this is not possible) before travel to, throughout stay in and for four weeks after leaving endemic area.
Can be taken for five years if considered necessary
Children’s doses
Calculate the dose by weight in kilograms (kg) rather than by the age for infants and children. The following doses are based on guidelines from the Public Health England Advisory Committee on Malaria Prevention (ACMP) and may differ from doses in patient information leaflets (PILs)/SPCs (off-licence doses should not be sold, but must be prescribed). Contact the NPA Pharmacy Services team for further advice.
Weight
Chloroquine
once weekly
OR
Proguanil
once daily
Under 6.0kg
1/4 tablet
1/4 tablet
6.0–9.9kg
1/2 tablet
1/2 tablet
10.0–15.9kg
3/4 tablet
3/4 tablet
16.0–24.9kg
1 tablet
1 tablet
25.0–44.9kg
1 and 1/2 tablets
1 and 1/2 tablets
45kg and over
2 tablets
2 tablets
NB: The dose steps for chloroquine syrup are not the same as for chloroquine tablets, because the tablets differ from the syrup in chloroquine base content. …
Proguanil and Chloroquine
Dosage schedule
Antimalarial
Dose
Schedule
Long term travel
Proguanil
2 x 100mg Paludrine® tablets daily.
Take one week (or at least two days if this is not possible) before travel to, throughout stay in and for four weeks after leaving endemic area.
Can be taken for five years if considered necessary.
PLUS
Chloroquine
2 x 250mg Avloclor® tablets once weekly.
Take one week before travel to, throughout stay in and for four weeks after leaving endemic area.
Can be taken continuously for three years. Beyond this, regular ophthalmic examinations are recommended every three to six months.
Children’s doses
Calculate the dose by weight rather than by the age for infants and children. The following doses are based on guidelines from Public Health England Advisory Committee on Malaria Prevention (ACMP) and may differ from doses in patient information leaflets (PILs)/SPCs (off-licence doses should not be sold, but must be prescribed). Contact the NPA Pharmacy Services team for further advice.
Weight
Proguanil
once daily
PLUS
Chloroquine
once weekly
Under 6.0kg
1/4 tablet
1/4 tablet
6.0–9.9kg
1/2 tablet
1/2 tablet
10.0–15.9kg
3/4 tablet
3/4 tablet
16.0–24.9kg
1 tablet
1 tablet
25.5–44.9kg
1 and 1/2 tablets
1 and 1/2 tablets
45kg and over
2 tablets
2 tablets
NB: The dose steps for chloroquine syrup are not the same as for chloroquine tablets, because the tablets differ from the syrup in chloroquine base content. …
Mefloquine or Doxycycline or Atovaquone/Proguanil
Dosage schedule
Antimalarial
Dose
Schedule
Long term travel
Mefloquine
1 x 250mg Lariam® tablet once weekly.
Take two to three weeks before travel to (to assess tolerability), throughout stay in and for four weeks after leaving endemic area.
Currently licensed for up to 12 months; however, can be taken safely for up to three years if considered necessary.
OR
Doxycycline
1 x 100mg Doxycycline tablet/capsule daily.
Take one to two days before travel to, throughout stay in and for four weeks after leaving endemic area.
Can be taken safely for up to two years and possibly longer if considered necessary.
OR
Atovaquone/proguanil
1 x (250mg/100mg) Atovaquone/proguanil tablet daily.
Take one to two days before travel to, throughout stay in and for seven days after leaving endemic area.
Can be taken for up to one year and possibly longer if considered necessary.However, individual SPCs must be checked carefully as licensed treatment periods may vary.
Children’s doses
Calculate the dose by weight in kilograms (kg) rather than by the age for infants and children. The following doses are based on guidelines from Public Health England Advisory Committee on Malaria Prevention (ACMP) and may differ from doses in patient information leaflets (PILs)/SPCs (off-licence doses should not be sold, but must be prescribed). …
