Mefloquine or Doxycycline or Atovaquone/Proguanil

Dosage schedule

Antimalarial Dose Schedule Long term travel
Mefloquine 1 x 250mg Lariam® tablet once weekly. Take two to three weeks before travel to (to assess tolerability), throughout stay in and for four weeks after leaving endemic area. Currently licensed for up to 12 months; however, can be taken safely for up to three years if considered necessary.

Doxycycline 1 x 100mg Doxycycline tablet/capsule daily. Take one to two days before travel to, throughout stay in and for four weeks after leaving endemic area. Can be taken safely for up to two years and possibly longer if considered necessary.

Atovaquone/proguanil 1 x (250mg/100mg) Atovaquone/proguanil tablet daily. Take one to two days before travel to, throughout stay in and for seven days after leaving endemic area. Can be taken for up to one year and possibly longer if considered necessary.However, individual SPCs must be checked carefully as licensed treatment periods may vary.

Children’s doses

Calculate the dose by weight in kilograms (kg) rather than by the age for infants and children. The following doses are based on guidelines from Public Health England Advisory Committee on Malaria Prevention (ACMP) and may differ from doses in patient information leaflets (PILs)/SPCs (off-licence doses should not be sold, but must be prescribed).  Contact the NPA Pharmacy Services team for further advice.

It is preferable to avoid crushing tablets; however, chloroquine, proguanil, mefloquine and atovaquone/proguanil tablets may be crushed and mixed with jam, honey, pasteurised yoghurt or similar for ease of administration to young children. Tablets may be cut using tablet cutters where necessary. Crushing, cutting or mixing tablets with foods/drinks may be off-licence, therefore, individual SPCs should be checked and specific manufacturers should be contacted.

* Mefloquine (1/4 tablet) may be advised for children weighing 5.0–9.9kg (licensed dose).

Weight Mefloquine
once weekly


once daily
Under 6.0kg *  

Not recommended

6.0–9.9kg 1/4 tablet Not recommended
10.0–15.9kg 1/4  tablet Not recommended
16–24.9kg 1/2 tablet Not recommended
25.0–44.9kg 3/4 tablet From 12 years: 1 capsule/tablet
45kg and over 1 tablet 1 capsule/tablet


Weight Atovaquone/proguanil
once daily
5.0 – 7.9kg ½ Malarone paediatric tablet
8.0 – 9.9kg ¾ Malarone paediatric tablet
10.0 – 19.9kg 1 Malarone paediatric tablet
20.0 – 29.0kg 2 Malarone paediatric tablets
30.0 – 39.9kg 3 Malarone paediatric tablets
> 40kg 4 Malarone paediatric tablets or 1 adult tablet