Important: EpiPen® 0.3mg adrenaline auto-injectors extended use beyond expiry dates for specific lot numbers

02 Oct 2019

The Medicines and Healthcare products Regulatory Agency (MHRA) has permitted the use of specific lot numbers of EpiPen® auto-injectors (AAI) 0.3mg for four months beyond the labelled expiry date

The Department of Health and Social Care (DHSC) are monitoring the overall market supply of the AAIs in the UK. In order to ensure patients have access to their AAI during the ongoing supply shortage, the Medicines and Healthcare products Regulatory Agency (MHRA) has permitted the use of specific lot numbers of EpiPen® auto injector 0.3mg for four months beyond the labelled expiry date. The MHRA has reviewed the stability data for the selected lot numbers and agreed that extension of use beyond the expiry date will temporarily improve patient access to and use of EpiPen® auto-injector 0.3mg.

The table below shows the specific lot numbers, which contain a labelled expiry date between September 2019 and December 2020

EpiPen® 0.3mg (single pack)

Lot Labelled expiry date
(end of the month)
Extended use by date
(end of the month)
8FA092T 09.2019 01.2020
8FA273E 11.2019 03.2020
8KB332M 02.2020 06.2020
8FA366K 02.2020 06.2020
8FA367B 02.2020 06.2020
8KB478B 04.2020 08.2020
8KB474B 04.2020 08.2020
8KB481B 04.2020 08.2020
8KB510G 05.2020 09.2020
8KB523G 05.2020 09.2020
8KB648B 06.2020 10.2020
8KB587B 06.2020 10.2020
8KB630C 06.2020 10.2020
8KB587F 06.2020 10.2020
8KB671R 07.2020 11.2020
9KB087B 10.2020 02.2021
9KB148B 10.2020 02.2021
9KB177AE 11.2020 03.2021
9KB262B 12.2020 04.2021

EpiPen® 0.3mg (twin pack)

Lot Labelled expiry date
(end of the month)
Extended use by date
(end of the month)
8KB558C 05.2020 09.2020
8KB630D 06.2020 10.2020
8KB671F 07.2020 11.2020
9KB148J 10.2020 02.2021
9KB177E 11.2020 03.2021
9KB252P 11.2020 03.2021
9KB301J 12.2020 04.2021
  • Extended use beyond the labelled expiry date only applies to EpiPen® 0.3mg auto injectors bearing the lot numbers above

Further information to support patients

  • Patients must continue to adhere to the manufacturer’s labelled expiry date on all EpiPen® auto-injectors 0.15mg and all other lot numbers of EpiPen® auto-injector 0.3mg which are not listed in the table above
  • Reassure patients that their AAI will continue to work safely within the extended use period
  • Show patients and carers where they can find the lot numbers on their AAI (the end-flap of the box or on the EpiPen® itself) and advise them to sign up to the Expiry Alert Service for additional support
  • Patients are recommended to always carry two AAI’s at all times

NPA members can access the latest adrenaline stock update on the NPA website. The availability information is updated regularly. Further guidance for patients, pharmacists and prescribers can be found on the EpiPen® website.

For further information on this or any other query, please contact the NPA Pharmacy team on 01727 891 800 or email pharmacyservices@npa.co.uk.

Produced by the NPA Pharmacy team September 2019.