Slo-phyllin® (theophylline) capsules – all strengths discontinued

28 Nov 2019

The manufacture of Slo-phyllin® (theophylline) capsules in all strengths has been discontinued

The Department of Health and Social Care (DHSC) has issued a supply disruption alert (SDA) stating that, Merck, the manufacturer of Slo-phyllin® (theophylline) capsules, has discontinued production of all strengths of this medicine due to manufacturing issues. There are no safety concerns with the product. It is anticipated that Slo-phyllin® capsules will be out of stock from the end of November 2019; there is limited stock available to order directly through Merck customer services team if it is unavailable from regular wholesalers.

Pharmacists and pharmacy teams should be aware that:

  • The DHSC has issued detailed guidance on options for patients requiring ongoing treatment as follows:
    • Details on suitable medicines that can be considered as alternatives, along with appropriate doses, are included in a table form
    • Requirements for monitoring of plasma theophylline levels
  • Pharmacists requested by prescribers to provide advice on clinically suitable alternatives should request a full medication history for the patient from the prescriber, where appropriate, before suggesting alternatives
    • It may be convenient to retain a hard copy of the SDA for pharmacists to use in the dispensary of busy pharmacies/pharmacies dispensing regular prescription for Slophyllin® capsules to aid discussions with prescribers

For further information on this or any other query, please contact the NPA Pharmacy Services team on 01727 891 800 or email

 Produced by the NPA Pharmacy Services team November 2019.